Regulation of Lipogenic Enzyme Induction
نویسندگان
چکیده
منابع مشابه
Regulation of lipogenic enzyme gene expression by nutrients and hormones.
In vivo and in vitro experiments strongly support the view that marked increases in the levels of mRNA and in the activities of lipogenic enzymes that occur in liver and white adipose tissue of the rat after weaning to a high-carbohydrate diet are dependent on an increase in plasma glucose and insulin concentrations. An increased glucose metabolism is necessary for the expression of insulin eff...
متن کاملSterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes.
To elucidate the physiological role of sterol regulatory element-binding protein-1 (SREBP-1), the hepatic mRNA levels of genes encoding various lipogenic enzymes were estimated in SREBP-1 gene knockout mice after a fasting-refeeding treatment, which is an established dietary manipulation for the induction of lipogenic enzymes. In the fasted state, the mRNA levels of all lipogenic enzymes were c...
متن کاملMlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes.
The expression of genes encoding enzymes involved in de novo triglyceride synthesis (lipogenesis) is transcriptionally induced in the liver in response to increased glucose metabolism. The carbohydrate response element-binding protein (ChREBP) is a newly identified basic helix-loop-helix/leucine zipper transcription factor proposed to regulate the expression of the glucose-responsive gene pyruv...
متن کاملSREBP-1-independent regulation of lipogenic gene expression in adipocytes.
Sterol regulatory element-binding protein (SREBP)-1c is now well established as a key transcription factor for the regulation of lipogenic enzyme genes such as FAS in hepatocytes. Meanwhile, the mechanisms of lipogenic gene regulation in adipocytes remain unclear. Here, we demonstrate that those in adipocytes are independent of SREBP-1c. In adipocytes, unlike in hepatocytes, the stimulation of ...
متن کاملNutritional and hormonal regulation of genes for lipogenic enzymes.
The de novo synthesis of long-chain fatty acids, a process that occurs primarily in liver in many species, is high in animals fed on diets with a high content of carbohydrate, and low in starved animals. The activities of the ‘lipogenic’ set of hepatic enzymes follow the same pattern. Two members of this lipogenic set are cytosolic malic enzyme (EC 1.1.1.40), which furnishes most of the NADPH f...
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ژورنال
عنوان ژورنال: Journal of Japan Oil Chemists' Society
سال: 1988
ISSN: 1884-2003
DOI: 10.5650/jos1956.37.820